ABSTRACT
Background: During the COVID-19 pandemic, outpatient clinics in National Guard-Health Affairs Hospitals, Saudi Arabia, have shifted their healthcare services towards virtual clinics to keep up with patient appointments while maintaining infection control precautions. This study aimed to determine if patient attendance compliance has changed by implementing virtual "phone call" appointments compared to the conventional physical appointments in outpatient clinics. Methods: This comparative cross-sectional study was conducted by comparing patients' demographic information, and compliance to virtual calls and physician recommendations during 2020 with the regular physical attendance clinics in 2019. Patient data was collected from the electronic medical records after randomly selecting the sample for each year from 6 main outpatient clinics. Results: During the 4-month period of 2020 (March-June), in which virtual clinics were implemented, there was a significant decrease in the attendance compliance when compared to the same period in 2019 conventional clinics. Data were analyzed for 404 and 407 patients' medical records from each year, respectively. The drop in the clinic attendance compliance was the highest in the pediatric oncology clinic. Moreover, physician orders of investigations and medications were significantly reduced. Conclusion: COVID-19 pandemic had a significant negative impact on patient care. Although that impact was seen greatest among those with chronic conditions and oncology patients, it was an essential step towards infection control during this difficult period. However, the pandemic is an opportunity to establish a comprehensive virtual care system that will ensure easy access and continuity of patient care. [ FROM AUTHOR] Copyright of Middle East Journal of Family Medicine is the property of Medi+WORLD International Pty. Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
ABSTRACT
OBJECTIVES: There is emerging evidence that SARS-CoV-2-specific memory T-cell responses are likely to provide critical long-term protection against COVID-19. Strategies to rapidly assess T-cell responses are therefore likely to be important for assessing immunity in the global population. METHODS: Here, we have developed a rapid immune-monitoring strategy to assess virus-specific memory T-cell responses in the peripheral blood of COVID-19 convalescent individuals. We validated SARS-CoV-2-specific memory T-cell responses detected in whole blood using in vitro expansion with SARS-CoV-2 proteins. RESULTS: T-cell immunity characterised by the production of IFN-γ and IL-2 could be consistently detected in the whole blood of recovered participants. T cells predominantly recognised structural SARS-CoV-2 proteins. In vitro expansion demonstrated that while CD8+ T cells recognised nucleocapsid protein, spike protein and ORF3a, CD4+ T cells more broadly targeted multiple SARS-CoV-2 proteins. CONCLUSION: These observations provide a timely monitoring approach for identifying SARS-CoV-2 cellular immunity and may serve as a diagnostic for the stratification of risk in immunocompromised and other at-risk individuals.